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KEY PUBLICATIONS

Submitted and Published Papers

A P2RY12 DEFICIENCY RESULTS IN SEX-SPECIFIC CELLULAR PERTURBATIONS AND SEXUALLY DIMORPHIC BEHAVIORAL ANOMALIES

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ASTROCYTES AND MICROGLIA IN THE COORDINATION OF CNS DEVELOPMENT AND HOMEOSRASIS

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DEFINING MICROGLIAL-SYNAPSE INTERACTIONS

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MICROGLIA PLAY BENEFICIAL ROLES IN MUTIPLE EXPERIMENTAL SEIXURE MODELS

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CAPILLARY-ASSOCIATED MICROGLIA REGULATE VASCULAR STRUCTURE AND FUNCTION THROUGH PANX1-P2RY12 COUPLING IN MICE

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A COMPARATIVE BIOLOGY OF MICROGLIA ACROSS SPECIES

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MICROGLIA PROVIDE STRUCTURAL RESOLUTION TO INJURED DENDRITES AFTER SEVERE SEIZURES

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PRECISE BRAIN MAPPING TO PERFORM REPETITIVE IN VIVO IMAGING OF NEURO-IMMUNE DYNAMICS IN MICE

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CALMING NEURONS WITH A MICROGLIAL TOUCH

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FULL LIST OF PUBLICATIONS WITH LINKS
 
AFTER 2018


OGOCHUKWU J. UWERU,AKHABUE K. OKOJIE, APARNA TRIVEDI, JORDAN BENDEROTH, LAUREN S. THOMAS, GEORGIA DAVIDSON, KENDAL. COX, UKPONG B EYO (2024). A P2RY12 DEFICIENCY RESULTS IN SEX-SPECIFIC CELLULAR PERTURBATIONS AND SEXUALLY DIMORPHIC BEHAVIORAL ANOMALIES. J NEUROINFLAMMATION. APRIL 15;21:95.


HONGBIN LI, UKPONG B. EYO (2024). THE DIVERSITY, DESTINY, AND MEMORY OF DAMs. IMMUNITY. FEB 13;57(2):200-202.



AIDA ORYZA LOPEZ, UKPONG B. EYO (2023). ASTROCYTES AND MICROGLIA IN THE COORDINATION OF CNS DEVELOPMENT AND HOMEOSTASIS. J NEUROCHEMISTRY. NOVEMBER 20.


AKHABUE K OKOJIE, JOSEPH O UWERU, MORGAN A COBURN, SIHAN LI, VIVIAN D CAO-DAO, UKPONG B EYO (2023). DISTINGUISHING THE EFFECTS OF SYSTEMIC CSF1R INHIBITION BY PLX3397 ON MICROGLIA AND PERIPHERAL IMMUE CELLS. J NEUROINFLAMMATION. OCT21;20(1):242.

UKPONG EYO AND ANNA VICTORIA MOLOFSKY (2023). DEFINING MICROGLIAL-SYNAPSE INTERACTIONS. SCIENCE. SEP 14; VOL 381 ISSUE 6663, P1155-1156.


GIBBS-SHELTON S, BENDEROTH J, GAYKEMA RP, STRAUB J, OKOJIE KA, UWERU JO, LENTFERINK DH, RAJBANSHI B, COWAN MN, PATEL B, CAMPOS-SALAZAR AB, PEREZ-REYES E, EYO UB (2023). MICROGLIA PLAY BENEFICIAL ROLES IN MUTIPLE EXPERIMENTAL SEIZURE MODELS. GLIA. JUL; 71(7):1699-1714. DOI: 10.1002/GLIA.24364.


LUKENS JR, EYO UB (2022). MICROGLIA AND NEURODEVELOPMENTAL DISORDERS. ANNU REV NEUROSCI. JUL 8;45:425-445. DOI:10.1146/ANNUREV-NEURO-110920-023056.



EYO, UB, HARUWAKA K, MO, MINGSHU, CAMPOS-SALAZAR AB, WANG L, SPEROS IV XS, SABU S, XU P, WU, LJ (2021). MICROGLIA PROVIDE STRUCTURAL RESOLUTION TO INJURED DENDRITES AFTER SEVERE SEIZURES. CELL REPORTS. MAY 4;35(5):109080. DOI: 10.1016/J.CELREP.2021.109080. [IF: 8.1]
 
SHARMA K, BISHT K, EYO UB. A COMPARATIVE BIOLOGY OF MICROGLIA ACROSS SPECIES. (2021) FRONTIERS OF CELLULAR DEVELOPMENTAL BIOLOGY. APR 1; 9:652748. DOI:10.3389/FCELL.2021.652748. [IF: 5.2]
 
MELSSEN MM, LINDSAY RS, STASIAK K, RODRIGUEZ AB, BRIEGEL AM, CYRANOWSKI S, RUTKOWSKI MR, CONAWAY MR, MELIEF CJM, VAN DER BURG SH, EYO U, SLINGLUFF CL, AND ENGELHARD VH. DIFFERENTIAL EXPRESSION OF CD49A AND CD49B DETERMINES LOCALIZATION AND FUNCTION OF TUMOR-INFILTRATING CD8+ T CELLS. (2021) CANCER IMMUNOL. RES. MAY; 9(5):583-597. DOI: 10.1158/2326-6066.CIR-20-0427. [IF: 8.7]

BADIMON A., STRASBURGER HJ, AYATA P, CHEN X, NAIR A, IKEGAMI A, HWANG P, CHAN AT, GRAVES SM, UWERU JO, LEDDEROSE C, KUTLU MG, WHEELER MA, KAHAN A, ISHIKAWA M, WANG Y-C, Y-HE LOH, JIANG JX, SURMELER DJ, ROBSON SC, JUNGER WG, SEBRA R, CALIPARI ES, KENNY PJ, EYO UB, COLONNA M, QUINTANA FJ, WAKE H, GRADINARU V AND SCHAEFER A. NEGATIVE FEEDBACK CONTROL OF NEURONAL ACTIVITY BY MICROGLIA. NATURE. DOI: HTTPS://DOI.ORG/10.1038/S41586-020-2777-8. [IF: 42.8]

BISHT K, SHARMA K, EYO UB. PRECISE BRAIN MAPPING TO PERFORM REPETITIVE IN VIVO IMAGING OF NEURO-IMMUNE DYNAMICS IN MICE. J VIS EXP. AUG 7; (162). DOI: 10.3791/61454. [IF: 1.2]

SHARMA K, WU LJ, EYO UB. CALMING NEURONS WITH A MICROGLIAL TOUCH. TRENDS NEUROSCI. 2020 APR; 43(4): 197-199. DOI: 10.1016/J.TINS.2020.01.008. EPUP 2020 FEB 15.

LIU YU, YING Y, LI Y, EYO UB, CHEN T, ZHENG J, UMPIERRE AD, ZHU J, BOSCO DB, DONG H, WU LJ (2019). NEURONAL NETWORK ACTIVITY CONTROLS MICROGLIAL PROCESS SURVEILLANCE IN AWAKE MICE VIA NOREPINEPHRINE SIGNALING. NAT NEUROSCI. NOV;22(11):1771-1781. DOI: 10.1038/S41593-019-0511-3. 
 
MO M, EYO UB, XIE M, PENG J, BOSCO DB, UMPIERRE AD, ZHU X, TIAN DS, XU P, WU LJ (2019). MICROGLIAL P2Y12 RECEPTOR REGULATES SEIZURE-INDUCED NEUROGENESIS AND IMMATURE NEURONAL PROJECTIONS. J NEUROSCI. 2019 20;39(47):9453-9464. DOI: 10.1523/JNEUROSCI.0487-19.2019.
 
ZHOU LJ, PENG J, XU YN, ZENG WJ, ZHANG J, WEI X, MAI CL, LIN ZJ, LIU Y, MURUGAN M, EYO UB, UMPIERRE AD, XIN WJ, CHEN T, LI M, WANG H, RICHARDSON JR, TAN Z, LIU XG, WU LJ (2019). MICROGLIA ARE INDISPENSABLE FOR SYNAPTIC PLASTICITY IN THE SPINAL DORSAL HORN AND CHRONIC PAIN. CELL REP. JUN 25;27(13):3844-3859.E6. DOI: 10.1016/J.CELREP.2019.05.087
 
EYO UB, WU LJ (2019). MICROGLIA: LIFELONG PATROLLING IMMUNE CELLS OF THE BRAIN. PROG. NEUROBIOL. AUG; 179: 101614. DOI: 10.1016/J.PNEUROBIO.2019.04.003.
 
UWERU JO, EYO UB (2019). A DECADE OF DIVERSE MICROGLIAL-NEURONAL PHYSICAL INTERACTIONS IN THE BRAIN (2008-2018). NEUROSCI LETT. JAN 6; 698:33-38. DOI: 10.1016/J.NEULET.2019.01.001. 
 
 
 
 
BEFORE 2018

BOSCO DB, ZHENG J, XU Z, PENG J, EYO UB, TANG K, YAN C, HUANG J, FENG L, WU G, RICHARDSON JR, WANG H, WU LJ (2018). RNASEQ ANALYSIS OF HIPPOCAMPAL MICROGLIA AFTER KAINIC ACID-INDUCED SEIZURES. MOL BRAIN. 2018 JUN 20;11(1):34. DOI: 10.1186/S13041-018-0376-5.

ZHAO, X, EYO UB, MURUGAN M, WU LJ (2018). MICROGLIAL INTERACTION WITH THE NEUROVASCULAR SYSTEM IN PHYSIOLOGY AND PATHOLOGY. DEV. NEUROBIOL. JUN; 78(6):604-617. DOI: 10.1002/DNEU.22576.
 

EYO UB, MO M, YI M-H , MURUGAN M, LIU J, YARLAGADDA R, MARGOLIS DJ, XU P, WU LJ (2018). P2Y12R-DEPENDENT TRANSLOCATION MECHANISMS GATE THE CHANGING MICROGLIAL LANDSCAPE. CELL REP. APR 24; 23(4):979-966. DOI: 1016/J.CELREP.2018.04.001.

EYO UB, BISPO A, LIU J, SABU S, WU RONG, DIBONA VL, ZHANG H, TANG Y, WU LJ (2018). THE GLUN2A SUBUNIT REGULATES NEURONAL NMDA RECEPTOR-INDUCED MICROGLIA- NEURON PHYSICAL INTERACTIONS. SCI REP. JAN 16;8(1):828. DOI: 10.1038/S41598-018- 19205-4.

TIAN D, PENG J, MURUGAN M, FENG L, LIU J, EYO UB, ZHOU LJ, MOGILEVSKY R, WANG W, WU LJ (2017). CHEMOKINE CCL2-CCR2 SIGNALING INDUCES NEURONAL CELL DEATH VIA STAT3 ACTIVATION AND IL-1Β PRODUCTION AFTER STATUS EPILEPTICUS. JOURNAL OF NEUROSCIENCE, AUG 16; 37(33):7878-7892. DOI: 10.1523/JNEUROSCI.0315-17.2017.

EYO UB, PENG, J, MURUGAN M, MO M, LALANI A, XIE P, XU P, MARGOLIS DJ, WU LJ (2017). REGULATION OF PHYSICAL MICROGLIA-NEURON INTERACTIONS BY FRACTALKINE SIGNALING AFTER STATUS EPILEPTICUS. ENEURO. DOI: 10.1523/ENEURO.0209-16.2016
 
EYO UB, MURUGAN M, WU LJ (2017). MICROGLIA-NEURON COMMUNICATION IN EPILEPSY. 
GLIA JAN; 65(1):5-18.. DOI: 10.1002/GLIA.23006.

GU N, PENG J, MURUGAN M, WANG X, EYO UB, SUN D, REN Y, DICICCO-BLOOM E, YOUNG W, DONG H, WU LJ (2016). SPINAL MICROGLIOSIS DUE TO RESIDENT MICROGLIAL PROLIFERATION IS REQUIRED FOR PAIN HYPERSENSITIVITY AFTER PERIPHERAL NERVE INJURY. CELL REPORTS. PII: S2211- 1247(16)30758-6. DOI: 10.1016/J.CELREP.2016.06.018.
 
PENG J, GU N, ZHOU L, B EYO U MURUGAN M, GAN WB, WU LJ (2016). MICROGLIA AND MONOCYTES SYNERGISTICALLY PROMOTE THE TRANSITION FROM ACUTE TO CHRONIC PAIN AFTER NERVE INJURY. NAT COMM. 7:12029. DOI: 10.1038/NCOMMS12029.

GU N, EYO UB, MURUGAN M, PENG J, MATTA S, DONG H, WU LJ (2016). MICROGLIAL P2Y12 RECEPTORS REGULATE MICROGLIAL ACTIVATION AND SURVEILLANCE DURING NEUROPATHIC PAIN. BRAIN BEHAV. IMMUN., JUL; 55: 82-92. DOI: 10.1016/J.BBI.2015.11.007.

EYO UB, MINER SA, WEINER JA, DAILEY ME (2016). DEVELOPMENTAL CHANGES IN MICROGLIAL MOBILIZATION ARE INDEPENDENT OF APOPTOSIS IN THE NEONATAL MOUSE HIPPOCAMPUS. BRAIN BEHAV. IMMUN., JUL; 55: 49-59. DOI: 10.1016/J.BBI.2015.11.009.

SWIATKOWSKI P, MURUGAN M, EYO UB, WANG Y, RANGARAJU S, OH SB, WU, LJ (2016). ACTIVATION OF MICROGLIAL P2Y12 RECEPTOR IS REQUIRED FOR OUTWARD POTASSIUM CURRENTS IN RESPONSE TO NEURONAL INJURY. NEUROSCIENCE, MAR 24 318:22-33. DOI: 10.1016/J.NEUROSCIENCE.2016.01.008.

LIU, J, TIAN, D, MURUGAN, M, EYO, UB, DREYFUS, CF, WANG, WU, LJ (2015). MICROGLIAL HV1 PROTON CHANNEL PROMOTES CUPRIZONE-INDUCED DEMYELINATION THROUGH OXIDATIVE DAMAGE. JOURNAL OF NEUROCHEMISTRY, OCT; 135(2): 347-356. DOI: 10.1111/JNC.13242.

EYO UB, GU N, DE S, DONG H, RICHARDSON JR, WU LJ (2015). MODULATION OF MICROGLIAL PROCESS CONVERGENCE TOWARDS NEURONAL DENDRITES BY EXTRACELLULAR CALCIUM. JOURNAL OF NEUROSCIENCE. FEB 11; 35(6): 2417-2422. DOI: 10.1523/JNEUROSCI.3279-14.2015.

EYO UB, PENG J, PRZEMYSLAW S, MUKHERJEE A, BISPO A, WU LJ (2014). NEURONAL HYPERACTIVITY RECRUITS MICROGLIAL PROCESSES VIA NEURONAL NMDA RECEPTORS AND MICROGLIAL P2Y12 RECEPTORS AFTER STATUS EPILEPTICUS. JOURNAL OF NEUROSCIENCE. AUG 6;34 (32): 10528-10540. 
 DOI: 10.1523/JNEUROSCI.0416-14.2014

DAILEY ME, EYO U, FULLER L, HASS J, AND KURPIUS D (2013) IMAGING MICROGLIA IN BRAIN SLICES AND SLICE CULTURES. COLD SPRING HARBOR PROTOCOLS (DECEMBER, 2013 JOURNAL COVER).DEC 1; (12):1142-8. DOI: 10.1101/PDB.PROT079483. 

EYO UB, MINER SA, AHLERS KE, WU LJ, DAILEY ME (2013). P2X7 RECEPTOR ACTIVATION REGULATES MICROGLIAL CELL DEATH DURING OXYGEN-GLUCOSE DEPRIVATION. NEUROPHARMACOLOGY, OCT; 73: 311-319. DOI: 10.1016/J.NEUROPHARM.2013.05.032.

EYO UB, DAILEY ME (2013) MICROGLIA: KEY ELEMENTS IN NEURAL DEVELOPMENT, PLASTICITY AND PATHOLOGY. JOURNAL OF NEUROIMMUNE PHARMACOL. 8 (3):494-509. DOI: 10.1007/S11481-013-9434-Z (JUNE, 2013 JOURNAL COVER) 

EYO UB, WU LJ (2013). BI-DIRECTIONAL MICROGLIA-NEURON COMMUNICATION IN THE HEALTHY BRAIN. NEURAL PLAST.2013: 456857. DOI: 10.1155/2013/456857.

EYO U, DAILEY ME (2012) EFFECTS OF OXYGEN-GLUCOSE DEPRIVATION ON MICROGLIAL MOBILITY AND VIABILITY IN DEVELOPING MOUSE HIPPOCAMPAL TISSUES. GLIA. 60(11):1747-1760. DOI: 10.1002/GLIA.22394. (NOVEMBER, 2012 JOURNAL COVER).

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